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Wahab et al

If phase 3 results remain positive, regulatory submissions may begin in 2026, meaning orforglipron could become available in late 2026 or 2027, depending on MHRA and NICE approval timelines

The compounds were intraperitoneally administered with the compound at 8 a.m

According to the review, [GLP-1 receptor] signaling in astrocytes regulates both central and peripheral metabolism, extending from energy balance to neuroplasticity. This signaling also enhances neuron growth, and an increase in astrocytes also increases neuron survival